Council's Research Work
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Item Physicochemical, pharmacognostic standardisation and phytochemical analyses of the homoeopathic drug Justicia adhatoda(Central Council for Research in Homoeopathy, 2025) Biswas, Bibaswan; Patel, Satish; Verma, Digvijay; Maity, SatyajitBackground: Justicia adhatoda (J. adhatoda), also well known as Vasaka in India is a medicinal plant chiefly used to treat respiratory ailments in traditional and alternative medical systems. Objective: This study aimed to establish the physicochemical, pharmacognostic, and phytochemical standardisation parameters of the drug. The study involved the measurement of physicochemical parameters and chemical profiling of the raw drug. The chemical characteristics of the in-house mother tincture (prepared from in-house raw drug) and commercial mother tinctures available in India were also evaluated to assess the quality of commercially available mother tinctures. Materials and Methods: The present study included pharmacognostic parameters like macroscopic, microscopic, powder studies and physicochemical parameters involving foreign matter, loss on drying, extractive values in different solvents, ash value measurements, total alkaloid content, total fixed oil and total volatile oil of the raw drug. This study also included measurement of various mother tincture parameters, such as organoleptic characteristics, specific gravity, pH, total solids, UV–Vis spectrum, high performance thin-layer chromatography (HPTLC), phytochemical screening, total alkaloid content, and chemical profiling of commercial and in-house mother tinctures to assess their comparative quality. Results: The macroscopic and microscopic studies revealed the pharmacognostic characteristics of the leaves. Low ash values indicated low metal contents. The chemical profiling and analysis indicated the presence of the same alkaloid in the raw drug and in the mother tinctures. The drug also contained several phytochemicals. Conclusion: The present study provides pharmacopoeial standards for J. adhatoda.Item Homoeopathic intervention in dual autoimmune disorders: A case report on management of vitiligo and hashimoto thyroiditis(Central Council for Research in Homoeopathy, 2025) Saklani, Nitin KumarBackground: Vitiligo and Hashimoto Thyroiditis often occur as chronic autoimmune disorders that require careful evaluation and individualised management. This case study examines the usefulness of homoeopathic interventions in addressing the complexities of Vitiligo and Hashimoto Thyroiditis through evidence-based methodologies. Case Summary: A 57-year-old woman initially sought medical attention for a noticeable whitish discolouration on the left side of her lips. Subsequent evaluations unveiled the presence of hypothyroidism, marked by elevated Anti-TPO levels, exposing the dual autoimmune nature of her condition. The patient’s concerns centered on the aesthetic impact of vitiligo on her lips and the broader health implications of Hashimoto’s Thyroiditis. The coexistence of vitiligo and Hashimoto’s thyroiditis required simultaneous evaluation of both dermatological and thyroid-related findings. The patient underwent homoeopathic treatment at the outpatient department of the Regional Research Institute for Homoeopathy, Shimla. Following the intervention, recovery from the signs and symptoms of both vitiligo and Hashimoto’s Thyroiditis was observed. Photographic evidence and serological investigations, including Serum TSH and anti-TPO, demonstrated significant improvement in the conditions. This evidence-based case report highlights the potential positive role of Homoeopathy in the management of complex dual autoimmune conditions, providing insights into the successful recovery of the patient both clinically and serologically.Item Indian Standard for Globules used in Homoeopathy(Central Council for Research in Homoeopathy, 2025) Vivekanand, Kumar; Katarmal, Daisy; Saxena, Indra Gaurav; Taneja, Divya; Dixit, Shrishti; Manchanda, Raj KumarThis article aims to describe and critically examine the Indian Standard (IS 18947:2024) for globules used in Homoeopathy, outlining the technical specifications, testing methods, and significance for pharmaceutical quality assurance. The implications of the standard for manufacturers, quality control laboratories, consumers and regulatory bodies engaged in the production and evaluation of homoeopathic drugs are highlighted by presenting a consolidated view of the standard’s scope and applications. This discussion underscores the continued importance of systematic standardization in ensuring the safety, consistency, and global credibility of homoeopathic medicinal products produced in India.Item Strengthening Homoeopathy with Standards: The BIS initiative(Central Council for Research in Homoeopathy, 2025) Manchanda, Raj K; Vivekanand, Kumar; Katarmal, DaisyItem Effectiveness of homoeopathic medicines in reducing the size of non-specific chronic leg ulcers - A single-arm, prospective observational study(Central Council for Research in Homoeopathy, 2025) Greeshma IK; Dastagiri PBackground: A chronic leg ulcer (CLU) is a chronic wound of the leg that does not tend to heal easily. Venous, arterial insu ciency, diabetes mellitus, or a combination of these factors may cause pain, restricted mobility, impaired social activities, and increased personal expenses, all of which can adversely affect the quality of life. Objectives: To determine the effectiveness of homoeopathic medicines in reducing the size of non-specific chronic leg ulcers using the Leg Ulcer Measurement Tool (LUMT) and changes in the quality of life by the Euro QoL (EQ-5D-3L) score. Materials and methods: A prospective clinical study was conducted at the National Homoeopathy Research Institute in Mental Health, Kottayam, India, from February 2021 to August 2022, and was registered in CTRI/2021/02/030951. Out of 35 cases, 34 completed the treatment for six months and were analyzed by evaluating the size of the ulcer, LUMT score, and Euro QoL score at baseline, as well as at the 3rd and 6th months. Results: Of 52 screened patients, 35 were enrolled and prescribed individualized homoeopathic medicine. Statistically significant reduction was observed in the size of the ulcer, from 5.6 cm2 to 0 and in the LUMT score from 31 to 7 (p<0.001). Furthermore, Euro QoL was also measured at baseline, and the results at 3rd and 6th months were compared and analyzed using Friedman’s test, with a significant reduction from 13 to 5 (p < 0.001). Lycopodium clavatum, Sulphur, Lachesis mutus, Phosphorus, Arsenicum album, Mercurius solubilis, Natrum muriaticum, and Pulsatilla nigricans were frequently indicated, and no serious adverse events were recorded during the study. Conclusion: The study determined that individualised Homoeopathy effectively reduces the size of non-specific chronic leg ulcers and improves patients’ QoL. Well-designed pragmatic trials are warranted.Item Potency dependent angiogenic effect of Bellis perennis on in ovo chick chorioallantoic membrane assay(Central Council for Research in Homoeopathy, 2025) Jayanthdevan V; Winston Vargheese V; Anish fathima K; Lohita SBackground: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis perennis 12X, 6CH, 30CH by assessing the angiogenic effect in chorioallantoic membrane assay (CAM). Methods: CAM assay was done following the standard protocol and the antiangiogenic and angiogenic effect of Bellis perennis in 12X, 6CH, and 30CH was assessed by counting the number of vessels and densitometry study using Image J software at 24 h, 48 h, and 72 hours(h). Histological study was carried out under light microscopy for tissue thickening. Results: Bellis perennis had antiangiogenic property in 12X and angiogenic property in 6CH and 30CH. Conclusion: Bellis perennis shows potency dependent angiogenic activity.Item Development and validation of Susceptibility Assessment Tool in Homoeopathy (SATH) in homoeopathic clinical practice(Central Council for Research in Homoeopathy, 2025) Taneja, Divya; Khurana, Anil; Dhawale, Kumar; Mittal, RenuBackground: The homoeopathic philosophy identifies susceptibility as a key concept for prescribing a similimum, i.e., the indicated remedy and its potency. No validated instrument to measure susceptibility as high, medium or low could be identified in the literature. Objective: The present study was undertaken to identify the factors governing susceptibility assessment and to develop a simple tool for physicians to assess the susceptibility of the cases they see in their clinical practice. Material and Methods: A new questionnaire was developed using standardised procedures including item development, pilot testing, and psychometric evaluation. The psychometric properties of this pilot tool were assessed by applying it on patients in routine clinical practice in different types of illnesses. Data was computerised and analysed by principal component analysis as an extraction method and orthogonal varimax as a rotation method. Results: The final 17-item questionnaire was arranged into nine domains as per rotated component matrix analysis. Overall internal consistency of the final questionnaire, as calculated by Cronbach’s alpha, was 0.607, and the measure of sampling adequacy was 0.729. Conclusion: A simple, homoeopathically appropriate, easy-to-use tool has been developed which can be applied by the practitioners during case taking to come up with a score, identifying low, normal or high susceptibility. This susceptibility assessment tool in Homoeopathy (SATH) can be further applied in diverse settings to enhance its validity and clinical utility.Item Evaluation of oral administration of Calendula officinalis among the centesimal potencies in acute wound healing in male wistar rats(Central Council for Research in Homoeopathy, 2025) George, A Vincer; Naik, Ramadas; Punchappady Devasya Rekha; Alva, MelitaBackground: Calendula o cinalis (Calendula) is used in Homoeopathy to treat various wounds. The presence of bioactive compounds results in pharmacological properties like wound healing, antioxidants, and anti-inflammatory properties. Hence, clinicians use different centesimal potencies (6C, 30C, 200C) to heal wounds. Objective: To compare the wound-healing potential of Calendula dilutions (6C, 30C, 200C) through oral administration in a pre-clinical acute wound model. Materials and Methods: The study involved administering Calendula centesimal potencies (6C, 30C, 200C) orally. Male wistar rats aged eight to ten weeks were involved in the experiment. Every animal had full-thickness excisional wound created on its back and assigned into four groups: vehicle control (VC) group and three treatment groups receiving oral doses of dispensing alcohol, Calendula 6C, Calendula 30C, and Calendula 200C, respectively. Each animal received treatment twice daily for seven days, with six-hour interval between doses. Wound photographs, taken at regular intervals, were used to observe the rate of wound closure. Animals were sacrificed on 8th and 14th days to collect samples for histopathology and immunohistochemistry. Results: Analysis of variance assessed the statistical significance of the group differences. The study showed that wound healing was significantly higher in Calendula-treated groups than in VC. The results indicate that wound closure, epidermal thickness, collagen deposition, and the proliferative marker antigen Kiel-67 (Ki-67) expression levels were significantly higher (p<0.01) in the Calendula 30C-treated group compared with other groups. Conclusion: Among the Calendula centesimal potencies tested for wound contraction, 30C proved to be the most effective for wound healing.Item A case report on multiple renal calculi and bilateral ovarian cysts treated with homoeopathic medicine Ignatia amara(Central Council for Research in Homoeopathy, 2025) Sharma, PragyaIntroduction: Renal calculi are the most frequent urological illness. It can be caused by genetic, nutritional, or environmental factors. Ovarian cysts are fluid-filled structures which can be simple or complex. It can affect females of any age, whether during puberty or menopause. These disorders remain a medical challenge due to their complex aetiology and high incidence. Sometimes the symptoms grow so severe for the patient that treatment and time lost from work involve substantial costs, compromising their social, physical, psychological, and financial well-being. Case summary: This is a case report of a 38-year-old female having sharp cutting pain in lumbar region for six months. The complaints were accompanied by profuse black menstrual bleeding, associated with lower abdominal pain before and during menses. This article explains a case of multiple renal calculi and bilateral ovarian cysts cured with well-selected homoeopathic remedy Ignatia amara, after detailed case taking and repertorisation, which improved the physical as well as mental well-being of the patient. Using the Modified Naranjo Criteria for Homeopathy (MONARCH), the causal attribution of homoeopathic treatment to the outcome was evaluated. This case report shows the usefulness of the homoeopathic medicine Ignatia amara on the basis of individualisation in cases of multiple renal calculi and bilateral ovarian cysts.Item Indian standard of plastic containers and closures for dispensing homoeopathic pharmaceutical preparations(Central Council for Research in Homoeopathy, 2025) Homoeopathy Sectional CommitteeHomoeopathic medicines require safe packaging to maintain their quality and effectiveness. Proper packaging prevents contamination, preserves potency, and ensures patient safety. Hence, Bureau of Indian Standards (BIS) had received the proposal from the Ministry of Ayush for the development of BIS standards for packaging material used for homoeopathic medicinal products (HMP). One such packaging is plastic containers. Accordingly, IS 19084: 2024 was developed and notified, which specifies requirements for plastic containers and closures used for packaging, storage, and dispensing of homoeopathic pharmaceutical preparations in solid and liquid dosage forms. This paper reports the details of the standard and the methodology adopted for its formulation.