Council's Research Work
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Item Physicochemical, pharmacognostic standardisation and phytochemical analyses of the homoeopathic drug Justicia adhatoda(Central Council for Research in Homoeopathy, 2025) Biswas, Bibaswan; Patel, Satish; Verma, Digvijay; Maity, SatyajitBackground: Justicia adhatoda (J. adhatoda), also well known as Vasaka in India is a medicinal plant chiefly used to treat respiratory ailments in traditional and alternative medical systems. Objective: This study aimed to establish the physicochemical, pharmacognostic, and phytochemical standardisation parameters of the drug. The study involved the measurement of physicochemical parameters and chemical profiling of the raw drug. The chemical characteristics of the in-house mother tincture (prepared from in-house raw drug) and commercial mother tinctures available in India were also evaluated to assess the quality of commercially available mother tinctures. Materials and Methods: The present study included pharmacognostic parameters like macroscopic, microscopic, powder studies and physicochemical parameters involving foreign matter, loss on drying, extractive values in different solvents, ash value measurements, total alkaloid content, total fixed oil and total volatile oil of the raw drug. This study also included measurement of various mother tincture parameters, such as organoleptic characteristics, specific gravity, pH, total solids, UV–Vis spectrum, high performance thin-layer chromatography (HPTLC), phytochemical screening, total alkaloid content, and chemical profiling of commercial and in-house mother tinctures to assess their comparative quality. Results: The macroscopic and microscopic studies revealed the pharmacognostic characteristics of the leaves. Low ash values indicated low metal contents. The chemical profiling and analysis indicated the presence of the same alkaloid in the raw drug and in the mother tinctures. The drug also contained several phytochemicals. Conclusion: The present study provides pharmacopoeial standards for J. adhatoda.Item Homoeopathic intervention in dual autoimmune disorders: A case report on management of vitiligo and hashimoto thyroiditis(Central Council for Research in Homoeopathy, 2025) Saklani, Nitin KumarBackground: Vitiligo and Hashimoto Thyroiditis often occur as chronic autoimmune disorders that require careful evaluation and individualised management. This case study examines the usefulness of homoeopathic interventions in addressing the complexities of Vitiligo and Hashimoto Thyroiditis through evidence-based methodologies. Case Summary: A 57-year-old woman initially sought medical attention for a noticeable whitish discolouration on the left side of her lips. Subsequent evaluations unveiled the presence of hypothyroidism, marked by elevated Anti-TPO levels, exposing the dual autoimmune nature of her condition. The patient’s concerns centered on the aesthetic impact of vitiligo on her lips and the broader health implications of Hashimoto’s Thyroiditis. The coexistence of vitiligo and Hashimoto’s thyroiditis required simultaneous evaluation of both dermatological and thyroid-related findings. The patient underwent homoeopathic treatment at the outpatient department of the Regional Research Institute for Homoeopathy, Shimla. Following the intervention, recovery from the signs and symptoms of both vitiligo and Hashimoto’s Thyroiditis was observed. Photographic evidence and serological investigations, including Serum TSH and anti-TPO, demonstrated significant improvement in the conditions. This evidence-based case report highlights the potential positive role of Homoeopathy in the management of complex dual autoimmune conditions, providing insights into the successful recovery of the patient both clinically and serologically.Item Indian Standard for Globules used in Homoeopathy(Central Council for Research in Homoeopathy, 2025) Vivekanand, Kumar; Katarmal, Daisy; Saxena, Indra Gaurav; Taneja, Divya; Dixit, Shrishti; Manchanda, Raj KumarThis article aims to describe and critically examine the Indian Standard (IS 18947:2024) for globules used in Homoeopathy, outlining the technical specifications, testing methods, and significance for pharmaceutical quality assurance. The implications of the standard for manufacturers, quality control laboratories, consumers and regulatory bodies engaged in the production and evaluation of homoeopathic drugs are highlighted by presenting a consolidated view of the standard’s scope and applications. This discussion underscores the continued importance of systematic standardization in ensuring the safety, consistency, and global credibility of homoeopathic medicinal products produced in India.Item Strengthening Homoeopathy with Standards: The BIS initiative(Central Council for Research in Homoeopathy, 2025) Manchanda, Raj K; Vivekanand, Kumar; Katarmal, DaisyItem A workshop on systematic review and meta-analysis: CCRH's capacity building initiative for evidence synthesis(Central Council for Research in Homoeopathy, 2025) Jain, Surbhi; Kaur, Harleen; Rani, Purnima; Singh, GurpreetThe workshop on ‘Systematic Review and Meta-Analysis for Beginners: A Practical Introduction’ was organised by Central Council for Research in Homoeopathy (CCRH) in hybrid mode on 13th and 14th August 2025 at the auditorium of the Ayush building in New Delhi, India. The workshop with 8 technical sessions conducted over a span of 2 days, was attended by more than 400 delegates across various units/institutes of CCRH. The aim was to build capacity of scientists/ researchers of CCRH about the conduct of systematic reviews and meta- analyses, as they represent the highest level in the hierarchy of scientific evidence and are pivotal in enhancing the credibility, integration, and application of Ayush systems in mainstream healthcare.Item Individualised homoeopathic treatment of menstrual distress in adolescent girls – A case series(Central Council for Research in Homoeopathy, 2025) Kalra, Neha; Saxena, Ritika; Narang, Anjula; Kaushik, SubhashIntroduction: Menstrual distress is a broad term describing the constellation of physical, emotional, and behavioural symptoms that occur about menstruation and cause discomfort or disruption to daily life. These symptoms can include abdominal cramps, backache, breast tenderness, mood swings, irritability and sleep disturbances. This complex impact extends beyond pain alone and reflects the multifaceted burden that menstruation may impose. This case series brings forth eight adolescent girls suffering from menstrual distress, who were successfully treated with individualised Homoeopathy. Case summary: The results of this case series demonstrate a mean reduction in total Menstrual Distress Questionnaire (MEDI-Q) score from baseline to six months from 15.4 to 0.0. Complete recovery of dysmenorrhoea, physical or/and psychological distress associated with menstruation was seen in all eight cases. Causal relationship between homoeopathic intervention and clinical outcome was done using Modified Naranjo Criteria (MONARCH). Further, randomised controlled trial of larger sample size are needed to validate the results.Item Homoeopathy during one hundred years of LMHI (1925–2025) – Part 1: Philosophical perspectives(Central Council for Research in Homoeopathy, 2025) Schmidt, Josef MThe celebration of 100 years of “Liga medicorum homoeopathica internationalis” (LMHI) in 2025 gives reason to reflect on the philosophical essence of Homoeopathy as well as its historical development within a dynamic, changing world up to now. From a philosophical perspective, in this first part, it is pointed out that Hahnemann, the founder of Homoeopathy, needs to be understood in his entirety – not only as a keen discoverer, practitioner and thinker, but also in his spiritual shape, i.e. in his ethical, religious and humanitarian attitude and conviction. Only thus may one grasp the significance of the schism pervading Homoeopathy’s history since the split of a major part of his “critical” pupils, adhering to a different, more relativistic and agnostic style of thinking, still during Hahnemann’s own lifetime. What followed was an antagonism in the history of Homoeopathy that still exists today – between so-called “true” “Hahnemannians” and so-called “free” and “scientific-critical” homoeopaths. On this paradigmatic basis, the history of the LMHI may be assessed and studied in a new (proper) light.Item Effectiveness of homoeopathic medicines in reducing the size of non-specific chronic leg ulcers - A single-arm, prospective observational study(Central Council for Research in Homoeopathy, 2025) Greeshma IK; Dastagiri PBackground: A chronic leg ulcer (CLU) is a chronic wound of the leg that does not tend to heal easily. Venous, arterial insu ciency, diabetes mellitus, or a combination of these factors may cause pain, restricted mobility, impaired social activities, and increased personal expenses, all of which can adversely affect the quality of life. Objectives: To determine the effectiveness of homoeopathic medicines in reducing the size of non-specific chronic leg ulcers using the Leg Ulcer Measurement Tool (LUMT) and changes in the quality of life by the Euro QoL (EQ-5D-3L) score. Materials and methods: A prospective clinical study was conducted at the National Homoeopathy Research Institute in Mental Health, Kottayam, India, from February 2021 to August 2022, and was registered in CTRI/2021/02/030951. Out of 35 cases, 34 completed the treatment for six months and were analyzed by evaluating the size of the ulcer, LUMT score, and Euro QoL score at baseline, as well as at the 3rd and 6th months. Results: Of 52 screened patients, 35 were enrolled and prescribed individualized homoeopathic medicine. Statistically significant reduction was observed in the size of the ulcer, from 5.6 cm2 to 0 and in the LUMT score from 31 to 7 (p<0.001). Furthermore, Euro QoL was also measured at baseline, and the results at 3rd and 6th months were compared and analyzed using Friedman’s test, with a significant reduction from 13 to 5 (p < 0.001). Lycopodium clavatum, Sulphur, Lachesis mutus, Phosphorus, Arsenicum album, Mercurius solubilis, Natrum muriaticum, and Pulsatilla nigricans were frequently indicated, and no serious adverse events were recorded during the study. Conclusion: The study determined that individualised Homoeopathy effectively reduces the size of non-specific chronic leg ulcers and improves patients’ QoL. Well-designed pragmatic trials are warranted.Item Potency dependent angiogenic effect of Bellis perennis on in ovo chick chorioallantoic membrane assay(Central Council for Research in Homoeopathy, 2025) Jayanthdevan V; Winston Vargheese V; Anish fathima K; Lohita SBackground: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis perennis 12X, 6CH, 30CH by assessing the angiogenic effect in chorioallantoic membrane assay (CAM). Methods: CAM assay was done following the standard protocol and the antiangiogenic and angiogenic effect of Bellis perennis in 12X, 6CH, and 30CH was assessed by counting the number of vessels and densitometry study using Image J software at 24 h, 48 h, and 72 hours(h). Histological study was carried out under light microscopy for tissue thickening. Results: Bellis perennis had antiangiogenic property in 12X and angiogenic property in 6CH and 30CH. Conclusion: Bellis perennis shows potency dependent angiogenic activity.Item 6C potency of Terminalia chebula reveals secondary metabolites and induces apoptosis in Triple-Negative Breast Cancer Cells (TNBCs)(Central Council for Research in Homoeopathy, 2025) Parimoo, Apoorva; Aphale, Shama; Patil, Prajakta D.; Ghanekar, Ruchika KaulBackground: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side effects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: Lactate release was studied by LDH assay, and mitochondrial membrane potential was evaluated by JC-1 assay. The mRNA expression of tumour suppressor and pro-apoptotic genes was done by qRT-PCR assay. Mother Tincture (MT) and 6C potencies were phytochemically characterised by LCMS analysis. Results: The 6C potency of TC increased lactate release in TNBCs, indicating a shift towards glycolysis and potentially inducing metabolic changes that contribute to its anticancer activity. The increased lactate release led to loss of mitochondrial membrane potential and an increase in mRNA expression of pro-apoptotic markers (caspase 3, caspase 9, and cytochrome c) and tumour suppressor proteins (p53 and pRb). LCMS analysis of 6C potency revealed phytocompounds with anticancer, anti-inflammatory, and antioxidant activities. Conclusion: The 6C potency of T. chebula induced apoptosis in TNBCs, however, further in vivo effi cacy and safety studies are warranted to understand the anti-cancer mechanism of 6C in-depth.