Council's Research Work
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Item The role of homoeopathic treatment in women suffering from post-caesarean backache: An open observational clinical trial(2019) Nath, ArunavaDe, MahadebSingh, SubhasKundu, NiveditaMichael, JamesSadhukhan, SatarupaContext: An open observational trial was carried out at National Institute of Homoeopathy, India, to assess the possible effects of individualised Homoeopathy in individuals suffering from post caesarean backache. Aim: The aim of the study was to find the role of homoeopathic treatment in individuals suffering from post caesarean backache. Methods: Fifty subjects were enrolled. The Short Form McGill Pain Questionnaire (SF MPQ) and Oswestry Low Back Pain Disability Questionnaire (ODQ) were used as the outcome measures, assessed at baseline and after 3 months of treatment. Medicines prescribed followed homoeopathic principles. Non-parametric Wilcoxon signed rank test was applied to compare the dependent observations. P < 0.05 two tailed was considered statistically significant. Results: Five subjects dropped out and 45 completed the trial. Intention to treat sample (n = 50) was analysed. There were statistically significant reductions in pain rating index percentage score (median 83.3 (IQR 66.7 to 100) vs. median 66.7 (IQR 33.3 to 71.1), P < 0.001); visual analogue scale score (median 7.0 (IQR 6.0 to 8.0) vs. median 6.0 (IQR 4.8 to 7.0), P < 0.001); present pain index score (median 3.0 (IQR 2.0 to 3.0) vs. median 2.0 (IQR 2.0 to 3.0), P = 0.019) and ODQ% score (median 44.0 (IQR 39.5 to 50.0) vs. median 39.0 (IQR 31.9 to 44.0), P < 0.001) over 3 months of treatment. Natrum muriaticum (n = 11, 22%); Staphysagria (n = 8, 16%); Bryonia alba and Rhustoxicodendron (n = 6 each, 12%) and Pulsatilla nigricans (n = 4, 8%) were prescribed frequently. Conclusion: Indicated homoeopathic medicines reduced SF MPQ and ODQ scores. Further randomised trials are warranted with enhanced methodological rigour.Item A review of Basic Research on Homoeopathy from a physicist’s point of view(2015) Nandy, PapiyaHomoeopathic medicine has been one of the world’s most widely practiced alternative therapies. However, that the potency of a homoeopathic medicine increases with dilution followed by succussion (together termed as potentization) has thrown challenges to the scientific community at large. A recent hypothesis, advanced by us and others, is that due to the process of potentization, the size of the constituent particles decreases and eventually reaches nanodimension. This decrease in size with increase in potency has been verified by scanning electron microscopy and dynamic light scattering studies. The increase in potency is manifested in its increased effect on membrane fluidity. The change in potency also leaves its signature on Ultraviolet–Visible spectra, Fourier transform infrared radiation spectra and Raman spectra. We have taken one step further to carry this nano?dimensional property of homoeopathic medicine and put it into several technical applications. And in so doing, we have connected the important, old, un?quantifiable effects with the latest quantifiable technology and opened up an era of applications with more possibilities.Item Research Highlights(2018)Item Resolution of vocal cord nodules with individualised homoeopathic treatment(2019) Parveen, SuraiaNath, RanitaVocal Cord Nodules (VCNs) are localised benign, superficial growths on the medial surface of the true vocal folds resulting primarily from voice abuse, overuse or misuse and clinically manifested by progressive hoarseness of voice, with increased effort required to produce the voice, vocal fatigue and discomfort or pain in the throat. Conventional treatment methods include conservative voice therapy and surgical intervention. Both treatment methods are required for the resolution of VCNs with improvement of clinical symptoms. Here, a 44 year old male teacher presented with a history of progressive hoarseness with vocal fatigue, discomfort in the throat during talking and bilateral VCNs since 8 months. There was no improvement after voice rest and voice therapy interventions for 5 months and he was finally advised for surgery, which he denied. He was, instead, successfully treated by individualised homoeopathic single medicine Heparsulphuricum (30C, 200C and 1M) selected on holistic approach. Over the period of 5 months of homoeopathic treatment, the patient’s presenting symptoms of VCNs were improved and with resolution of it. This case report suggests that homoeopathic intervention may be the treatment for the resolution of VCNs with its presenting symptoms.Item Pre?clinical pharmacology: An important aspect in homoeopathic research(2018) Gupta, PankajSundaram, E. N.Sharma, MahimaPrajapati, SuneelArya, B. S.Khurana, AnilManchanda, Raj K.Background: Before the 20th century, research in Homeopathy was limited either for its proving in healthy human volunteers or to its clinical verification/clinical efficacy in diseased individuals. However, in recent years, there has been an increased trend in the number of pre?clinical studies aimed to evaluate the pharmacological activity produced by homeopathic medicines. The objective of this review is to make a systemic compilation of results of experimental pharmacological findings of homeopathic medicines, both in vitro and in animal models, and to present the same in a summarised form. Methods: Articles published up to March 2017 having information of in vitro and in vivo studies using homeopathic medicines were collected from the PubMed database, review articles, scientific reports, research articles, thesis, online information extracted from Medline, etc. to compile this review. The articles from the most common therapeutic areas such as antimicrobial effect, central nervous system disorders, anti?inflammatory and analgesic, anticancer, wound healing, antiasthmatic and liver toxicity and other therapeutic areas such as diabetes and malaria were included in this review. Results: This review article not only provides the scientific approaches applied in Homeopathy research but also provides evidence?based information on pharmacological effects of dilutions/potencies as well as mother tincture of different homeopathic drugs. This review article also reveals the use of improved methodology, molecular techniques and analytical part adopted in recently published research articles to understand the mechanism of action of homeopathic medicines. Conclusion: Homeopathy has substantial scope in pre?clinical research where therapeutic and biological effects of homeopathic medicines with proper mechanism of action can be traced out with the use of modern molecular techniques in in vivo and in vitro experiments.Item Homoeopathic approach for the treatment of cancer(2018) Ahmad, SaeedRehman, TayyebaAbbasi, Waheed MumtazHomoeopathy is among the commonly used alternative approaches in Cancer. It is being widely used as palliative and curative in patients suffering from cancer. Though studies on the use of Homoeopathy in cancer after surgery, radio therapy and chemotherapy have been reported, clinical trials on effects of Homoeopathy in cancer are rare. Some studies on the effect of dosage of Homoeopathic medicines and their mechanism of action in cancer have also been published. A few case reports published here and there also find a mention in different databases. This review aims to describe literature available on the approach of Homoeopathy in Cancer by searching various databases like Elsevier, Google Scholar, Pub Med, Scopus, Springer and Wiley online library, electronically. It was found that beneficial effect of Homoeopathic medicines are reported on some cancer cell lines via apoptosis and immune modulation. Homoeopathic treatment given as add on also improves the quality of life, survival time and presenting complaints. However, more evidence needs to be generated to demonstrate anti tumor or antimetastatic potential in controlled clinical trials.Item Retrospective estimation of prevalence and likelihood ratio of general symptoms of 29 less frequently prescribed homoeopathic medicines by clinical verification(2019) K. Manchanda, RajChakraborty, ParthasarathiKoley, MunmunSingh, DineshSingh, PramodjiSingh, OjitGayatri Prasad, VaranasiContext: Scientific assessment of proving symptoms or already recorded symptoms in patients refers to Clinical Verification (CV). There are serious shortcomings of existing methods of CV, mostly arising from qualitative observations made on absolute occurrence of symptoms instead of relative ones. This problem can be resolved by the use of the Likelihood Ratio (LR). Aim: This study aims to estimate the prevalence and LRs of general symptoms of 29 less frequently prescribed homoeopathic medicines. Methods: The study was multicentric, open and observational. Patients were enrolled as per pre specified eligibility criteria. Alongside, presenting complaints and general symptoms were taken into account during prescription. Medicines were prescribed in centesimal potencies. LR calculation of general symptoms was based on clinician rated outcomes as ‘improved’ and ‘not improved’ of presenting complaints and was divided into three sections: (1) when the prevalence of a symptom was available from literature, LR was calculated by assessing the prevalence of that symptom in the responder sample, (2) in the absence of so, calculation was restricted to mean prevalence data from study sample (‘confined LR’) and (3) ‘confined LRs’ were not calculated for symptoms whose prevalence were not recorded for at least five medicines and were kept for estimation in future. Results: Of 166 general symptoms of 29 medicines, LRs and confined LRs >1.5 were elicited for 6 and 49 symptoms, respectively. Conclusion: In spite of considerable caveats, it is the first insight into prevalence and LRs of general symptoms of less frequently prescribed homoeopathic medicines. Further research is warranted.Item Item Research design in Homoeopathy: A perspective(2019) Khurana, Anil