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Indian Journal of Research in Homoeopathy

Permanent URI for this collectionhttps://aoh.ccrhlibrary.in/handle/123456789/38

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Start date: 2024Has files: Yes

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    Investigation of molecular footprints in ultra-high diluted homoeopathic solutions of Arnica montana Arnica montana andand Rhus toxicodendron through combined infrared and impedance spectroscopy
    (CCRH, 2026) Kundu, Sharbadeb; Dash, Usha Rani; Chaudhuri, Chirasree Roy
    Background:Background: The study of ultra-high diluted (UHD) solutions is a compelling and controversial domain in modern science. Despite numerous investigations and hypotheses, there is a lack of rigorous, reproducible empirical evidence supporting the existence of molecular footprints beyond the Avogadro's limit. Objective:Objective: This study conducted a detailed investigation of the molecular and electrical properties, focusing on hydrogen bonding and impedance to understand the fundamental nature of UHD solutions. Materials and methods:Materials and methods: Combined impedance and infrared spectroscopic investigations were performed to probe the structural behaviour of relevant water networks at the molecular level of UHD alcoholic extract of Arnica montana (AM) and Rhus toxicodendron (RT). Results:Results: At higher potencies (200C and 1M) of both AM and RT, an interesting correlation was observed between impedance and spectral characteristics. An increase in impedance was observed with potencies for both AM (93.9%) and RT (49%), which was attributed to changes in the hydrogen bonding network and molecular reorganisation during potentisation. This correlates with the Mid-IR spectra, showing increased hydrogen bond length and potential weakening of inter-molecular hydrogen bonds with increasing potency. Also, Far-IR spectra indicate a contrast in the system's enthalpic gain with increased potencies for both AM (29.8%) and RT (65.2%). Conclusion:Conclusion: Distinct variations in spectral and electrical parameters have been observed for AM and RT due to potentisation, suggesting that these solutions retain structural and molecular traits despite extreme dilutions. This notion may revisit traditional homoeopathic treatment approaches by addressing conflicting paradigms regarding the presence of molecular footprints in UHD solutions.
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    Fundamental research principles in Homoeopathy
    (CCRH, 2026) Shekhar, Himanshu; Aphale, Parth; Dokania, Shashank
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    Bridging the gap in women's healthcare
    (CCRH, 2026) Kaushik, Subhash
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    Research Highlights
    (CCRH, 2026) Gupta, Meenu; Shanker, Sunaina
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    Screening of antiurolithiatic activity of different formulations of homoeopathic medicines using calcium oxalate crystallisation assay
    (CCRH, 2026) G, Loganathan; T, Satesh
    Background: Homoeopathic medicines such as Aerva lanata, Hydrangea arborescens, Berberis vulgaris, and Sarsaparilla are commonly used to treat kidney stones. Scientific research is needed to understand their effects on calcium oxalate crystallisation, a key factor in urolithiasis. Objective: The study evaluated the in vitro effects of Aerva Lanata, Hydrangea Arborescens, Berberis Vulgaris, and Sarsaparilla in Q, 6C, and 30C potencies on calcium oxalate crystallisation. It aimed to identify which potency had the strongest inhibitory effect compared to Ethanol (90%). Methods: Calcium oxalate (CaOx) crystals were synthesised by mixing calcium chloride and sodium oxalate, then cooled to 37 °C to achieve a concentration of 0.8 mg/mL in Tris buffer (pH 6.5). Homoeopathic remedies (Aerva lanata, Berberis vulgaris, Hydrangea arborescens, and Sarsaparilla in Q, 6 C, and 30 C potencies) and ethanol (90%) were tested at concentrations of 1000 to 10 μg/ml. After 24 hours at 37 °C, turbidity was measured, and crystal morphology was examined under an inverted light microscope. Results: Aerva lanata Q, Aerva lanata 6C, and Berberis vulgaris Q significantly inhibited stone formation compared to the ethanol control group, with Aerva Lanata Q demonstrating the most pronounced effect. Light microscopy revealed diverse crystal morphologies, underscoring the role of Calcium Oxalate crystals in kidney stone formation. Conclusion: Aerva lanata and Berberis vulgaris show potential in inhibiting calcium oxalate crystal formation, suggesting a role in preventing urolithiasis.
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    Homoeopathy during one hundred years of LMHI (1925–2025) – Part 2
    (CCRH, 2026) Schmidt, Josef M
    Taking Hahnemann in his entirety, as a paradigmatic example of a true homoeopath, as a sound basis for a proper understanding of Homoeopathy, the “scientific-critical” school of homoeopaths seems to miss one constitutive part of Homoeopathy: its spiritual embedment into a greater frame of thinking and feeling. In fact, the greatest successes of Homoeopathy, in terms of popularisation, institutionalisation and implementation into social and cultural practice, were achieved in countries and periods open towards spiritual dimensions. This was the case in North America at the end of the 19th century, when James Tyler Kent propagated a Hahnemannian Homoeopathy inspired by Emanuel Swedenborg, and in India and Latin America in the 20th century, where Kentianism fell on fertile ground, later being elaborated into different innovative schools. In Europe and North America, the New Age Movement in the 1970s brought a temporary opening for spiritual and esoteric ideas – to be followed by a drawback into the “critical-scientific” approach, in the wake of evidence-based medicine in the 1990s. The founding of the LMHI 100 years ago by Pierre Schmidt and others proved to be crucial for the spreading and advancement of genuine Homoeopathy according to Hahnemann.
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    Holistic approach of Homoeopathy in treatment of multimorbidity
    (CCRH, 2026) Verma, Divya; Saklani, Nitin Kumar; Arun Kumar
    Introduction: Multimorbidity, a rise in all ages, is a challenge for health care systems that are focused on single-disease management. Homoeopathy has shown competence in the management of chronic diseases, whether they occur as a single ailment or as multimorbidities. Case Summary: A 25-year-old female suffering from symptoms of PCOS, like irregular menses, secondary dysmenorrhea and secondary amenorrhea, along with chronic migraine visited the OPD. She also developed renal calculi during the previous homoeopathic treatment. Her condition improved through homoeopathic medicines Pulsatilla and Lycopodium. The case is reported according to HOM-CASE guidelines. The assessment of causal attribution of homoeopathic treatment was carried out using the Modified Naranjo Criteria, and VAS was used as the pain assessment for difficulty arising from menses, headache and renal calculi. MIDAS was used to determine disability due to migraine. The patient eventually reported regularity of menstrual cycles, reduction in pain during menses, and resolution of ovarian cysts. Migraine and renal calculi were also reported to be relieved as per the MIDAS score and ultrasound report, respectively. This case report suggests an encouraging role of constitutional treatment through individualised homoeopathic medicines in treating multimorbidity. However, more case studies and well-designed controlled research are warranted to further investigate the effect of homoeopathic intervention in multimorbidity.
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    Mitochondria-mediated apoptotic induction byMitochondria-mediated apoptotic induction by Chionanthus Chionanthus virginica virginica Q: A cytotoxic and oxidative stress-driven approach in Q
    (CCRH, 2026) Nair, Arun R; Hariram, Venkateshan; Arul, Vettrivel
    Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with current therapeutic options limited by late-stage detection, recurrence, and toxicity. Alternative treatments derived from medic-inal plants are gaining attention due to their potential anticancer properties. Chionanthus virginica, traditionally used for liver disorders, contains bioactive compounds with hepatoprotective and antioxidant effects. However, its anticancer potential remains largely unexplored. Objective: This study evaluates the antioxidant, cytotoxic, and apoptotic effects of Chionanthus virginica in mother tincture (Q) and potentised (12C) forms on HepG2 liver cancer cells to determine its efficacy as a natural anticancer agent. Materials and methods: HepG2 cells were treated with Chionanthus virginica Q and 12C across defined exposure levels (50–1000 μL/mL; extract-equivalent for Q and volume-equivalent for 12C). Antioxidant activity was determined using the DPPH assay, while MTT and LDH assays assessed cytotoxicity. Mitochondrial dysfunction was analysed via MMP and cytochrome c release assays, ROS generation was measured by DCFH-DA fluorescence, and caspase activity was quantified using a colorimetric assay. Results: Chionanthus virginica Q showed the strongest antioxidant activity (IC50 = 101.49 μg/mL) and higher cytotoxicity (CTC50 = 330.35 μg/mL), while the response observed with Chionanthus virginica 12C was interpreted only as a biological effect under volume-equivalent exposure conditions. One-way and two-way ANOVA were performed for statistical significance. LDH release, cytochromec translocation, and ROS levels increased significantly (p < 0.001), leading to mitochondrial depolarisation and caspase activation, confirming apoptosis. Conclusion: This study demonstrates that Chionanthus virginica Q induces apoptosis in HepG2 cells via oxidative stress and mitochondrial dysfunction, supporting its potential as a natural anticancer agent. Further studies should focus on bioactive compound isolation and in vivo validation.
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    Homoeopathic management of mania with psychotic symptoms
    (CCRH, 2026) Bhuvaneswari, R; V, Sakthivel
    IntroductionIntroduction: Manic episode (ICD-F30.2) is typically characterised by distinct period of abnormally and persistently elevated, expansive, or irritable mood, along with abnormally and persistently increased goal-directed activity or energy, lasting at least 1 week and causing significant disruption in occupational and social functioning. The lifetime risk of experiencing manic episodes is approximately 0.8–1%. These episodes typically recur in three to four-month cycles. This case report aims to highlight significance of individualised homoeopathic treatment in managing mania with psychotic symptoms over a 41-month period without relapse, and without the use of conventional medication. Case Summary:Case Summary: An 18-year-old female was brought by her parents to the psychiatry outpatient department on August 1, 2022 with complaints of agitation, anger, and irritability, reduced sleep, abusive language, suspiciousness, and pressured speech. She believed her parents were hacking her phone and harming her since 12 days. A consultant psychiatrist diagnosed her with mania with psychotic symptoms, and the severity was measured using the YMRS and BPRS scales. Lachesis 200C was prescribed, followed by a single dose ofCarcinosinum 200C as constitutional medicine. The YMRS score dropped from 48 to 0 within a week, and the BPRS score from 70 to 0 in three months, with no homoeopathic aggravation noted. MONARCH, score 7, suggests a causal attribution to disease improvement. Thus, indicating a correlation between medication and outcome. There was a significant improvement change within a week. Homoeopathic medicines selected based on individualisation are effective in the treatment of mania with psychotic symptoms.
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    Non-invasive treatment for indolent chronic venous ulcer using individualised Homoeopathy
    (CCRH, 2026) Ramanan, Vinitha Edavattath; KP, Geethu
    Background: Venous ulcers account for 60–70% of all leg ulcers. They are irregular ulcers with sloping edges mainly seen above the medial malleolus associated with oedema, lipodermatosclerosis and hemosiderosis. Conventional medicine mentions chronic venous ulcers as a surgical disease. It usually results in further co-morbidities and reduces the patient’s quality of life. Homoeopathic literature describes many medicines for the treatment of varicose ulcers. This case series demonstrates the role of homoeopathic treatment in the complete healing of venous ulcers non-invasively. Case Summary: This is a case series of five patients suffering from chronic venous ulcers resistant to conventional external medications who visited the OPD of National Homoeopathy Research Institute in Mental Health Kottayam, Kerala, India during 2022–23. All the cases received individualised homoeopathic medicines internally. Conclusion: The ulcers healed completely within an average two-month period in all five cases, evidenced by images taken before and after treatment. The MONARCH score was calculated as +9/13, +8/13, +8/13, +8/13, and +8/13 for the five cases, indicating a definitive causal relationship between the medicine prescribed and the treatment outcome in the first case and probable relationship in the rest of the cases. Sulphur was prescribed in three cases, Pulsatilla and Arsenicum album in the rest of the cases. This case series suggests individualised Homoeopathy can help to treat venous ulcers.